Physical and functional interaction of human nuclear uracil-DNA glycosylase with proliferating cell nuclear antigen
نویسندگان
چکیده
منابع مشابه
Physical and functional interaction of human nuclear uracil-DNA glycosylase with proliferating cell nuclear antigen.
Uracil residues arise in DNA by the misincorporation of dUMP in place of dTMP during DNA replication or by the deamination of cytosine in DNA. Uracil-DNA glycosylase initiates DNA base excision repair of uracil residues by catalyzing the hydrolysis of the N-glycosylic bond linking the uracil base to deoxyribose. In human cells, the nuclear form of uracil-DNA glycosylase (UNG2) contains a conser...
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Proliferating cell nuclear antigen (PCNA) acts as a sliding clamp on duplex DNA. Its homologs, present in Eukarya and Archaea, are part of protein complexes that are indispensable for DNA replication and DNA repair. In Eukarya, PCNA is known to interact with more than a dozen different proteins, including a human major nuclear uracil-DNA glycosylase (hUNG2) involved in immediate postreplicative...
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The cell cycle stimulation of individual species of the uracil DNA glycosylase was examined in WI-38 normal diploid fibroblasts. The nuclear uracil DNA glycosylase was induced as WI-38 cells traversed the cell cycle. In contrast, the specific activity of the mitochondrial glycosylase remained constant during cell proliferation. The two enzyme activities can be further distinguished by their elu...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2005
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2005.08.006